Faculty Profile

Md. Zafrul Hasan, PhD

Associate Professor

Contact Information

  • Office Address: Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet-3114, Bangladesh
  • Phone: +8801706247124
  • Email: zafrul-bmb@sust.edu, jafrul05@yahoo.com

Biography

Zafrul has received his Ph.D. in Medical Sciences and the focus was on Anti-HIV immunity from Kumamoto University, Kumamoto, Japan. He has completed several postdoctoral training in Japan and Singapore. The postdoctoral research focus was on Alzheimer's, Autoimmunity, and Lipid Transporters in targeted transgenic and knockout mice models. Zafrul completed his master’s and bachelor’s degree in the “Dept. of Biochemistry and Molecular Biology” at the University of Dhaka, Dhaka, Bangladesh. After his master’s, he worked as a Research Officer in Virology Laboratory, icddr,b, Dhaka. Nowadays Dr. Zafrul serves the BMB department at SUST as a faculty member with others. Exploring new places, and new cultures, making friends, driving, watching movies, and taking challenges are the few things Zafrul likes most.

Education

  • PhD Medical Sciences (Anti-HIV immunity (2012), Kumamoto University, Kumamoto, Japan.
  • Master of Science in Biochemistry and Molecular biology (2003), University of Dhaka, Dhaka, Bangladesh.
  • Bachelor of Science in Biochemistry and Molecular biology (2002), University of Dhaka, Dhaka, Bangladesh .
  • Higher Secondary School Certificate Examination (1998), Dhaka College, Dhaka, Bangladesh.

Research Interests

  • Advanced molecular Immunology
  • Neurobiology
  • Epidemiology and Public Health
  • Lipid Transporter and Autoimmunity

Active Research Project

  • 1. Prediction of polymorphic plasticity of HIV-1 Rev protein by bioinformatical approaches, funded by SUST Research centre.

Previous Research Project

  • 1. JunB protein as a candidate biomarker in cancer diagnosis and its therapeutical implication, funded by SUST Research centre.

Journal Publications

  • 1. Marzan AA, Hasan MS, et al. Impact of betel quid on hyperglycemia among diabetes patients in Bangladesh. J Adv Biotechnol Exp Ther. 2024; 7(3): 460-471.
  • 2. Abdullah Al Marzan, Shatila Shahi, Md Sakil Arman, Hasan Z, Ajit Ghosh. Probing biologicalnetwork in concurrent carcinomas and Type-2 diabetes for potential biomarker screening: An advanced computational paradigm (2023). Advances in Biomarker Sciences and Technology,Vol.5, 89-104.
  • 3. Le, T., Nguyen, T. Q., Kalailingam, P., Nguyen, Y., Sukumar, V. K., Tan, C., Tukijan, F., Couty, L., Hasan, Z., Del Gaudio, I., Wenk, M. R., Cazenave-Gassiot, A., Camerer, E., & Nguyen, L. N. (2022). Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock. Cell reports, 40(7), 111208. https://doi.org/10.1016/j.celrep.2022.111208; IF: [9.95]
  • 4. Hasan, Z., Nguyen, T. Q., Lam, B., Wong, J., Wong, C., Tan, C., Yu, J., Thiam, C. H., Zhang, Y., Angeli, V., & Nguyen, L. N. (2022). Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions. Cellular and molecular life sciences : CMLS, 79(11), 541. https://doi.org/10.1007/s00018-022-04573-y; IF: [9.26]
  • 5. Mohammad Abul Hasnat, Md. Waseque Mia, Saifuddin Sarker, Md. Belal Chowdhury, Musaddik Ahmed Chowdhury, Md. Zafrul Hasan. Accessing the prevalence of cancer biomarkers in suspected patients from northeastern part of Bangladesh. J Adv Biotechnol Exp Ther. 2022; 6(1): 276-285.
  • 6. Mohammad Abul Hasnat, Farhan Rahman Niloy, Arafat Islam Ashik, Mahedi Hasan, Preonath Chondrow Dev, Sharmin Sultana Panna, Md. Waseque Mia, Hasan Z. Prevalence of hyperlipidemia in controlled and uncontrolled type-2 diabetic patients. J Adv Biotechnol Exp Ther. 2022; 5(1): 247-256.

  • 7. IKamori D, Hasan Z, Carlson J, Kawana-Tachikawa A, Gatanaga H, Oka S, Ueno T. Impact of Human Leukocyte Antigen-Associated Polymorphisms on Variability of HIV-1 Accessory and Regulatory Proteins. AIDS Res Hum Retroviruses. 2021 Apr 30. doi: 10.1089/AID.2021.0055. Epub ahead of print. PMID: 33757299. [IF=1.85]
  • 8. #Chandrakanthan M, #Nguyen TQ, #Hasan Z, Muralidharan S, Vu TM, Li AWL, Le UTN, Thi Thuy Ha H, Baik SH, Tan SH, Foo JC, Wenk MR, Cazenave-Gassiot A, Torta F, Ong WY, Chan MYY, Nguyen LN. Deletion of Mfsd2b impairs thrombotic functions of platelets. Nat Commun. 2021 Apr 16;12(1):2286. doi: 10.1038/s41467-021-22642-x. PMID: 33863882; PMCID: PMC8052357; [IF=17.69]; # Contributed Equally
  • 9. Nguyen TQ, Vu TM, Tukijan F, Muralidharan S, Foo JC, Chin JFL, Hasan Z, Torta F, Nguyen LN. Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b. J Biol Chem. 2020 Dec. Epub ahead of print. PMID: 33334894. [IF: 5.486]
  • 10. Kalailingam P, Wang KQ, Toh XR, Nguyen TQ, Chandrakanthan M, Hasan Z, Habib C, Schif A, Radio FC, Dallapiccola B, Weiss K, Nguyen LN. Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome. J Clin Invest. 2020 Aug 3. PMID: 32369449. [IF: 19.46]
  • 11. Hasan Z, Hasan M, Ashik AI, Mahtarin R, Newaj MA, Nishat ZS, Hasnat MA, Mia MW. Prediction of immune pressure on HIV-1 regulatory gene tat by human host through bioinformatics tools. 2020. J Adv Biotechnol Exp Ther. 2020 Sep; 3(3): 233-240.
  • 12. Hasnat MA, Mia MW, Hasan Z, Panna SS. Prevalence of Acinetobacter Infection in Hospital Environment and their Antimicrobial Sensitivity Pattern in North-East Region of Bangladesh. 2019. IRJPMS.ISSN (Online): 2581-3277.
  • 13. Hasan Z, Koizumi SI, Sasaki D, Yamada H, Arakaki N, Fujihara Y, Okitsu S, Shirahata H, Ishikawa H. JunB is essential for IL-23-dependent pathogenicity of Th17 cells. Nat Commun. 2017 May 30. PMID: 28555647. [IF: 17.69]
  • 14. Elahi M, Motoi Y, Matsumoto SE, Hasan Z, Ishiguro K, Hattori N. Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice. Neurosci Lett. 2016 Jan 1. PMID: 26592481. [IF: 2.274]
  • 15. Elahi M, Hasan Z, Motoi Y, Matsumoto SE, Ishiguro K, Hattori N.Region-Specific Vulnerability to Oxidative Stress, Neuroinflammation, and Tau Hyperphosphorylation in Experimental Diabetes Mellitus Mice. J Alzheimers Dis. 2016 Feb 25. PMID: 26923011. [IF: 3.909]
  • 16. Kamori D, Hasan Z, Ohashi J, Kawana-Tachikawa A, Gatanaga H, Oka S, Ueno T. Identification of two unique naturally occurring Vpr sequence polymorphisms associated with clinical parameters in HIV-1 chronic infection. J Med Virol. 2016 June 22. PMID: 27328918. [IF: 2.021]
  • 17. Meribe SC, Hasan Z, Mahiti M, Mwimanzi F, Toyoda M, Mori M, Gatanaga H, Kikuchi T, Miura T, Kawana-Tachikawa A, Iwamoto A, Oka S, Ueno T. Association between a naturally arising polymorphism within a functional region of HIV-1 Nef and disease progression in chronic HIV-1 infection. Arch Virol. 2015 Jun 10. PMID: 26060058. [IF: 2.243]
  • 18. Hasan Z, Doreen Kamori, and Ueno T. Role of host immune responses in sequence variability of HIV-1 Vpu. World J Immunol 2014 July 27. ISSN 2219-2824 (http://www.wjgnet.com/2219-2824/pdf/v4/i2/107.pdf).
  • 19. Motozono C, John J. Miles, Hasan Z, Gatanaga H, Stanley C. Meribe, David A. Price, Oka S, Andrew K. Sewell, and Ueno T. CD8+ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS One. 2013 Jun 17. PMID: 23799076. [IF: 2.740]
  • 20. Hasan Z, Carlson JM, Gatanaga H, Le AQ, Brumme CJ, Oka S, Brumme ZL, Ueno T. Minor contribution of HLA class I-associated selective pressure to the variability of HIV-1 accessory protein Vpu. Biochem Biophys Res Commun. 2012 May 4. PMID: 22503975. [IF: 2.985]
  • 21. Mwimanzi P, Hasan Z, Hassan R, Suzu S, Takiguchi M, Ueno T. Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages. Retrovirology. 2011 Jun 22. PMID: 21696586. [IF: 4.183]
  • 22. Mwimanzi P, Hasan Z, Tokunaga M, Gatanaga H, Oka S, Ueno T. Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection. Biochem Biophys Res Commun. 2010 Dec 17. PMID: 21093412. [IF: 2.985]
  • 23. Rahman M, Hassan ZM, Hasan Z, Saiada F, Banik S, Faruque AS, Delbeke T, Matthijnssens J, Van Ranst M, Azim T. Sequence analysis and evolution of group B rotaviruses. Virus Res. 2007 Feb 12. PMID: 17292993. [IF: 2.934]

Teaching

  • Introductory Biochemistry
  • Genomics
  • Proteomics
  • Basic and advanced Immunology
  • Metabolism
  • Advanced Molecular Biology
  • Plant Biochemistry

Awards & Recognition

  • Monbukagakusho scholarship 2008, Ministry of Education, Culture, Sports, Science and Technology Japan, MEXT.
  • Junior Research Associate (JRA) supporting grant (500,000 yen) 2009, Center for AIDS Research, Kumamoto University; Global GCOE program, Japan.
  • Junior Research Associate (JRA) supporting grant (400,000 yen) 2010, Center for AIDS Research, Kumamoto University; Global GCOE program, Japan.
  • Global Health Travel Award Scholarship 2010, Keystone Symposium, Calgary (Banff), Canada (HIV vaccines X5), funded by Bill & Melinda Gates Foundation.
  • Junior Research Associate (JRA) supporting grant (400,000 yen) 2011, Center for AIDS Research, Kumamoto University; Global GCOE program, Japan.
  • Global Health Travel Award Scholarship 2011, Keystone Symposium, Whistler, BC Canada (HIV Evolution, Genomics and Pathogenesis, X7), funded by Bill & Melinda Gates Foundation.
  • Support project of conference travel expenses for graduate student’s scheme (60,000 yen) 2011, Japanese Society for Immunology, 2011; Kumamoto University.
  • Junior Research Associate (JRA) supporting grant (250,000 yen) 2012, Center for AIDS Research, Kumamoto University; Global GCOE program, Japan.

Graduate Supervision

  • 1. Current students: 05